Cancer is difficult to treat due to its early immune invasion and metastasis. In the study presented here, the frequently used chemotherapeutic drugs 5-flourouracil and cisplatin are encapsulated in TPP cross-linked chitosan nanoparticles and their in vitro anti-cancer effect is investigated.
Eye diseases are difficult to treat due to natural factors such as the blood-eye barrier, cornea or tear film. Polymer-based nanoparticles made of chitosan, among others, can help there to improve drug transport. In this article we would like to summarize a review on this topic.
Berlin, Halle, 16.03.2023: Since January of this year, the project "Zielwirk" is developing a new chitosan technology for the efficient release of mRNA active ingredients. The technology aims to ensure that drugs for the treatment of serious diseases can be better absorbed as well as processed by the body. The participating project partners Heppe Medical Chitosan GmbH, FDX Fluid Dynamix GmbH, Martin Luther University Halle-Wittenberg and the Fraunhofer Institute for Production Systems and Design Technology (IPK) are funded by the German Federal Ministry of Economics and Climate Protection (BMWK) with six million euros over three years.
Small interfering RNAs (siRNAs) can be used as in gene therapies for e.g. cancers such as leukemia. However, the application of these is limited by a lack of efficient drug delivery. Therefore, in the presented study, chitosan was functionalized with arginine to form nanoparticles, loaded with siRNA, and their properties as siRNA vectors were investigated.
Glioblastomas are difficult to treat due to the blood-brain barrier and drug resistance. To improve the efficacy of treating glioblastomas with selenium nanoparticles (Se-NPs), Se-NPs were coated with chitosan in the presented study.
Vaccines based on recombinant protein antigens often require immunostimulants. Both nanoparticles and chitosan and its derivatives can enhance immunogenicity. For this reason, in the presented studies, PLGA nanoparticles were functionalized with different chitosan derivatives and optimized as effect enhancers for the pneumococcal protein antigen PspA4Pro.
Due to the increase of infectious diseases and the development of antibiotic resistance, new antibacterial substances are needed. In the presented study, novel chitosan-AgIO3 bionanocomposites were synthesized and their antibacterial properties were investigated.
Medical masks proved effective in protecting against the virus during the Covid-19 pandemic. However, conventional masks are poorly biodegradable. For this reason, the presented paper produced environmentally friendly chitosan/silver/plant fiber membranes for masks, which also exhibited antibacterial and thermal properties.
Breast cancer will affect one in eight women during their lifetime. Especially metastatic breast cancer has a low survival rate. In this article, we present a review of current research on the use of chitosan in breast cancer therapy and diagnostics.
Fungi of the Candida genus can be responsible for serious skin infections, especially as biofilms. To find an alternative treatment method for fungal biofilms, chitosan-gold nanoparticles were coupled with the quorum sensing molecule Tyrosol in the study presented here.
CRISPR/Cas is a promising tool to tackle genetic diseases. However, non-viral vectors with good transfection efficiency often struggle with high cytotoxicity. In the presented paper, calcium nanoparticles were modified with chitosan. The effects on transfection efficiency and cytotoxicity were then investigated.
Around one third of all type-2 diabetes sufferers develop diabetic foot ulcers in the course of their disease. Due to biofilm formation and multi-resistant bacteria, inflammation occurs in 50% of those affected. This article presents a study investigating the treatment of these with chitosan-containing metallic nanoparticles coupled to toluidine blue as a photosensitizer.
A large number of reviews on Chitosan were also published in 2021. According to HMC searches in the PubMed database, a total of 181 new reviews with chitosan in the title appeared in 2021. In this article, we would like to give you an overview of the publications, as well as briefly introduce five reviews on various topics related to chitosan. Have fun reading!
Various polysaccharides such as chitosan and β-glucan possess immunological properties that are advantageous for vaccine adjuvants. Therefore, in the presented study, chitosan and carboxymethyl-β-glucan were combined as nanoparticles, coupled to the model antigen ovalbumin as vaccine adjuvant and investigated in vivo in a mouse model.
The global corona pandemic requires effective vaccines to achieve herd immunity. In the study presented here, an inhalable chitosan-based nanovaccine containing the viral spike protein (S) was developed to specifically induce immunity at the mucosal sites of the respiratory tract.
Chitosan shows great potential as part of drug release systems of orally administered drug formulations. Another interesting use is as an antigen platform for vaccines. We present an article in which pneumococcal membrane protein-loaded chitosan capsules were prepared and evaluated for their efficacy for a nasally administered vaccine.
The importance of antibiotics remains undiminished today. However, antibiotic resistance is increasing and few new agents are being discovered that can bypass them. In the following article, a chitosan-based nanomaterial was therefore developed that exploits the antimicrobial effect of chitosan to eliminate Salmonella typhimurium.
Chitosan and chitosan derivatives are promising biopolymers for nasal or vaginal drug delivery using micro- or nanoparticles. However, the pH-dependent solubility of chitosan and excessive water uptake in the presence of ions is suboptimal. Water uptake can result in rapid initial release of the drug due to collapse of the chitosan-based transport vehicle. To stabilize the drug release, research is being conducted to modify the polymer structure by physical crosslinking. Aim of the presented study was to investigate the influence of microparticle composition, in particular the amount of ion crosslinker (CF) introduced, on the release profile of water-soluble drugs from the chitosan matrix.
Glaucoma is a group of diseases of the eye with damaged optic nerve and retina in advanced stages, possibly leading to blindness. One of the causes is increased intraocular pressure. Here, we present two publications, which investigated the combination of chitosan and curcumin for treatment of glaucoma and cancer patients.
In recent decades, there have been major advances in regenerative medicine, such as the treatment of severe nerve injuries. Implants used as scaffolds for nerve cell regeneration are often made of biodegradable polymers, such as chitosan. Below, we present a study that investigated the degradation and stability of tubular chitosan-based implants.
In the current corona pandemic, the protection of medical personnel who have contact with Covid-19 infected patients is important, also to ensure stability of the health care services. The personal protective equipment of hospital staff includes particle filtering respiratory masks. From early 2021, a clinical study will be conducted to investigate the protective effect of a new type of respirator with a filter element containing chitosan nanoparticles in Brazil. More about this study and other current clinical studies with chitosan in this article.
Chitosan is a promising drug delivery system for pulmonary applications and is therefore of particular interest for vaccine development in the Corona Pandemic. The biodegradable and biocompatible polymer's mucoadhesive, permeation-increasing and site-/cell-specific properties are useful in this context. Nanocarriers based on various microencapsulation and micro-nano mixing systems have already been developed. The aerodynamic character is important to enable efficient pulmonary aerosol formation and inhalation. In this article we present research on chitosan as pulmonary particulate anti-infective drug carrier.
Chitosan nanoparticles can deliver drugs to their specific target site and release them over a long period. In current corona crisis, chitosan nanoparticles could be one way to release potential COVID-19 drugs specifically in the lungs of affected patients. A potential drug delivery system for the treatment of SARS-CoV-2 infected persons is Novochizol™, consisting of chitosan-based nanoparticles.
Adjuvants in vaccines are potent enhancers, which ensure that even small amounts of pathogens induce a permanent immune response. They are particularly necessary for inactivated vaccines and vaccines with antigen subunits. Several studies investigated chitosan as an adjuvant or antigen delivery system in various formulations (gels, aqueous dispersion, micro- and nanoparticles).
There are many potential applications of gold nanoparticles in medicine. Gold nanoparticles are already being used in diagnostics, as in pregnancy or HIV tests [1]. Research on the use as a contrast agent for the localization of cancer cells and as a drug delivery system for targeted release at site of action. The surface properties of gold are optimal for functionalization, e.g. with chitosan.
Also in 2018, scientists around the world have been feverishly researching chitosan in a variety of applications. Often involved is chitosan of highest quality, produced by Heppe Medical Chitosan. At the end of the year, we would like to present articles in which HMC Chitosan has been researched for removal of drugs in water and antibacterial action.
Worldwide, our chitosan and chitosan derivatives are used in research. We created a list of scientific articles published in 2018 using chitosan from HMC. Nanoparticles from chitosan or chitosan derivatives were most frequently produced and tested for a wide variety of applications, mainly directed drug delivery and tissue engineering. Curious where to find chitosan by HMC in research?
At the end of the year we want to give you an overview about chitosan-related publications in 2016 and in the second part we focus on a quite different application of chitosan – how human and veterinary vaccines could benefit from chitosan as adjuvant.
Today´s topic is chitosan for drug delivery systems. In July and August 2016, 33 articles about chitosan combined with drug delivery systems were published. As might be expected, top publisher are China (13 articles), United States (5) and India (4). The articles investigated drug release by chitosan-based micro- or nanoparticles, hydrogels and nanocomposites. Thereby controlled release of cytostatics, proteins or peptides was mainly studied. (Source: www.gopubmed.org)
70 Publications with the chitosan topic were published in Febuary. In the ranking of nations China (14) was on the first place, followed by Iran (8) and India (8). Scientific Report – Nature published the article of Kamat V. et al. from Agharkar Research Institute in India.
In January were 77 publications with chitosan topics published. In addition to China (26) and the United States (11), Egypt (6) is on the third place of nations with the most publications.
In April 139 publications have been released about chitosan, which mainly focused on topics like evaluation studies, pharmaceutical preparations and nanoparticles. The leading nations in the field of chitosan research are China (48 articles), India (18) and USA (13).
In September and October 2013, 290 publications about chitosan and its diverse derivatives have been released. They present novel formulations of chitosan-based nanoparticles and pharmaceutical preparations and performed animal and human studies. The leading nations in chitosan research are China (75 articles), India (37) and USA (27).
231 articles about chitosan and chitosan derivatives have been published in May and June 2013. The main topics focused on animal and human studies and on chitosan-based nanoparticles and pharmaceutical preparations. Moreover, the physico-chemical properties and pH sensitivity of various chitosan derivatives were intensively studied. Among the top nations of chitosan research are again: China (76 articles), USA (30) and India (14).
At the end of the year 2014 numerous articles about chitosan and chitosan derivatives were published. All in all 312 reports were released in November and December by leading scientists from China (89 articles), USA (35) India (28) and South Korea (21).
In the mid-year, 227 articles have been released about chitosan. The main topics addressed nanoparticles, pharmaceutical preparations, evaluation studies, animals and humans. The leading nations in publishing chitosan-related articles are again China (69 articles), USA (28) and India (21). German scientists published 5 reports.
At the beginning of 2014, a variety of highly interesting chitosan-related articles were released by scientists from all over the world. All in all, 281 novel articles have been published, which promise new insights into the diversity of the biopolymer. The most successful nations in the field of chitosan research are again China publishing 88 articles, USA 33 reports and India contributed 23 articles.
In March 2015, 201 articles about chitosan and chitosan derivatives have been published. The main topics address chitosan in evaluation studies, nanoparticles, pharmaceutical preparations and tissues. Among the top countries of chitosan research are again: China (51 articles), India (23) and USA (21).
After an excellent start in January 2015, the number of chitosan-related articles slightly decreased in February. Scientific journals released 142 publications, which mainly focused on pharmaceutical preparations, nanoparticles and evaluation studies. Again, the three leading nations in chitosan research are China (40 articles), India (19) and USA (13). German scientists are placed among the top 10, as they contributed 5 reports.
At the beginning of the year 2015, an incredible large number of chitosan-related articles have been released, indicating another record year. All in all, 196 publications about chitosan and its derivatives were contributed by scientist from all over the world, especially from China (46 articles), India (29) and USA (15). The main terms address chitosan in evaluation studies, nanoparticles and pharmaceutical preparations.
In March and April 262 publications were released about Chitosan, which mainly focused on animal and human studies, nanoparticles and pharmaceutical preparations. The most successful nations in the field of chitosan research have been: China (83 articles), India (31) and USA (22).
The antimicrobial effect of chitosan is well known and has already been used in dentistry to prevent caries as well as in the food packaging industry as a preservative agent.
Overall 131 articles about chitosan and chitosan derivatives were published in March 2012.
As in the previous month, China is the country with the most publications with overall 35 articles, followed by the USA (14 articles), India (9 articles) and Taiwan (8 articles).
January opens the publication year 2012 with overall 159 articles about chitosan. Almost one third of the articles was published in China.
China: 56 articles
India: 15 articles
USA: 14 articles
Tawain: 7 articles
In September a total of 62 articles were published in the field of chitosan. In this month the most publications came from China where 10 articles were published. With 7 articles India was in second place followed by the USA where 6 articles were published.
In the februar of this year 81 papers about chitosan and its derivates were published. As in the months before also in February china was with 21 publications the most active country in this field of research followed by the USA with 12 publications and India with 4.
Starting in a new year in January 2011 92 articles about chitosan and its derivates were published. The top themes in the last month were evaluation studies, studies in tissues and about nanoparticle with 26, 25 and 21 publications.
In December 2010 116 articles dealing with chitosan or chitosan derivates were published. With 31 publications about chitosan China is the country which publicized the most ones followed by USA with 10 publications and India with 9. There chitosan nanoparticles, evaluation studies and pharmaceutical preparations were of most interest (37, 34 and 33 publications).
Bruno Alonso and Emmanuel Belamie of the Charles Gerhardt Institute in Montpellier, France developed a new large-scale synthesis of bioorganic-inorganic nanocomposites: self-organising chitin-silicon dioxide nanocomposites with unpredecented specificity in texture and structure of the product.
The big challenge in the field of medical innovations is so tiny that it is not noticeable with the naked eye. Nanotechnology – a promising and trendsetting technology. For example, with the help of drug-delivery-systems drugs can be transported to an exactly defined part within the body.
Chitosan also produces nanoparticles.
Der Sommer neigt sich zum Ende – das heißt aber nicht, dass die News rund um Chitosan nicht heiß sind. Hier der Review der Chitosan Veröffentlichungen im August. 97 wissenschaftliche Artikel wurden veröffentlicht, in denen mit Chitosan gearbeitet wurde. Im Int J Biol Macromol wurden 8 Artikel veröffentlicht. Die Top drei Nationen bezogen auf die Anzahl der Artikel sind China, USA und Indien, gefolgt von Portugal auf Platz 4.
In July several outstanding articles about chitosan had been published around the world. All in all 122 articles were released in 67 different journals. With regard to the number of publications the leading countries are China (31), the USA (20) and South Korea (10).
Chitosan is employed in many domains. Besides medical areas like e.g. as support in wound healing or in tissue engineering chitosan can also be applied in the fields of food technology and water management. Thanks to scientists of the faculty of Microsystems Technic at the Univesity of Stuttgart, chitosan might soon become part of biocompatible fuel cells.
In the first two months of this year numerous articles about chitosannanoparticles has been published into the following journals: biomaterials [6], biomed mater res a [2], j mater sci-mater m [2], langmuir [2], biomacromolecules [2]. The Authors are from Asia, Europe and Northamerica.
Chitosan - NanoBioSaccharides brightens up the darkNanoBioSaccharides - a project that aimed to unravel the properties of an apparent panacea is now concluded. During the last three years over 600 researchers from seven nations, managed by Prof. Dr. Bruno Moerschbacher of the University of Muenster dedicated their time to study the striking abilities of Chitosan and its application in human medicine. In Nanobiotechnology a breakthrough is expected, that will lead to significant changes on the one hand in the field of the delivery of medical bio-materials, drugs and genes and on the other hand in the area of cell- and tissue-engineering.
