Publications in February 2011

In the februar of this year 81 papers about chitosan and its derivates were published. As in the months before also in February china was with 21 publications the most active country in this field of research followed by the USA with 12 publications and India with 4.

The most frequent keywords in the papers about chitosan and its derivates were nanoparticles (23 publications), microscopy, hydrogen-ion concentration and tissues (each with 19 publications). In the table below the 5 journals with the most publications about chitosan and its derivates are listed.

Top Journale	Publikationen
Colloids Surf B Biointerfaces	13
Int J Pharm	4
Int J Biol Macromol	4
Biomacromolecules	4
Biomaterials	4

Table: Journals with the most publications about chitosan and its derivatives

Following three publications about properties and application of chitosan from February shall be shortly presented.

Enhancing effect of N-octyl-O-sulfate chitosan on etoposide absorption

Authors: Mo, Ran, Xiao, Yanyu, Sun, Minjie, Zhang, Can, Ping, Qineng, Journal: International journal of pharmaceutics, 2011

Etoposide (VP16) is a substrate of the p-glycoprotein (P-gp) which is expressed in the apical membranes of the epithelial cells of the intestine and is responsible for reducing oral bioavailability of a wide range of drugs. Mo et al. analyzed the effect of N-octyl-O-sulfate chitosan (NOSC) on the absorption of etoposide. Different concentrations of NOSC are able to increase the intestinal absorption of VP16 in rat jejunum and ileum and the VP16 uptake of Caco-2 cells. There were no differences observed in comparison to other P-gp inhibitors. By using NOSC at a concentration close to its critical micelle concentration the group found a cell uptake of VP16 which reached to the maximum value. NOSC exhibited the ability to increase the transport of VP16 from apical side to basolateral side whereas from basolateral to apical side the transport was decreased.
PMID: 21356302 Related Articles

A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action

Authors: Dowling, Matthew B, Kumar, Rakesh, Keibler, Mark A, Hess, John R, Bochicchio, Grant, Raghavan, Srinivasa R, Journal: Biomaterials, 2011

The working group of Dowling used a hydrophobically modified (hm) derivative of chitosan to transform blood rapidly into a gelled clot. They showed that this process can be reversed by the use of a sugar-based supramolecule like α-cyclodextrin. The contact of hm chitosan with heparinized human blood resulted in a rapidly transformation of the blood into an elastic gel. Native chitosan didn´t function in that way. Dowling et al. proved that hm chitosan is able to accelerate hemostasis in small and large animal injury models. Hm chitosan could serve as an effective, low cost hemostatic dressing.
PMID: 21296412 Related Articles

A glucose biosensor based on chitosan-Prussian blue-multiwall carbon nanotubes-hollow PtCo nanochains formed by one-step electrodeposition

Authors: Che, Xin, Yuan, Ruo, Chai, Yaqin, Li, Jingjing, Song, Zhongju, Li, Wenjuan, Zhong, Xia, Journal: Colloids and surfaces. B, Biointerfaces, 2011

Che et al. developed a glucose sensor by preparing a chitosan-Prussian blue-multiwall carbon nanotubes-hollow PtCo nanochains film onto the gold electrode surface and subsequently glucose oxidase and Nafion were modified onto the film. Therefore they used a simple one-step-electrodeposition method. The biosensor had a limit for detection of 0,47 µm glucose, showed a high sensitivity of 23,4μAmM(-1)cm(-2) and exhibit a linear measuring from 1,5µm – 1,12mM glucose. Additional it had a short reaction time. The results were good reproducible and the biosensor was very stable.
PMID: 21334863 Related Articles

Source: www.gopubmed.org