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Chitin

Chitin belongs to the biopolymer group and its fibrous structure is similar to cellulose.

Chemical name: (1,4)-N-acetyl-D-glucos-2-amine
Empirical formula: (C8H13NO5)n
CAS: 1398-61-4

The monomers are identified as N-Acetyl-Amnioglucose.  Chitin is a polysaccharide containing nitrogen in which monomers occur with the glycosidically linked components beta 1,4.  It is the same coupling as glucose with cellulose, however in chitin the hydroxyl group of the monomer is replaced with an acetyl amine group.  The resulting, stronger hydrogen bond between the bordering polymers makes chitin harder and more stabile than cellulose.

chitin_chitosan_2
Structure Chitin / Chitosan: 50% deacetylizated

Chitin was first isolated and characterized in 1811 by the chemist and botanist Henry Braconnot.

Occurrence in nature

  • in the exoskeleton of animals such as shrimp, crabs, krill, squid and insects or in cell walls of fungi, yeast and other microorganisms.
  • the amount of chitin in marine biomass alone is approx. 106-107 tons.
chitin_2
Structural formula Chitin

A distinction is made between alpha, beta and gamma chitin, which have different mechanical properties depending on the arrangement of the polymer chains.

  • Alpha: alternating antiparallel arrangement of polysaccharide chains (crustaceans)
  • Beta: parallel chain arrangement (squid)
  • Gamma: two parallel chains statistically alternating with an antiparallel chain (fungi)

Function of chitin in nature

  • supporting function (structural substance)
  • protection of soft parts (offers protection to inner organs)
  • prevention of loss of fluids

Solubility

  • insoluble in water, organic solvents, weak acids and lyes
  • soluble in concentrated formic acid and methane sulfonic acid,
  • strong acids split chitin into acetic acid and D-amino glucose (monomer of chitin), strong lyes split chitin into acetic acid and chitosan.

Biodegradability

  • through the enzymes chitinases and lysozyme to chitobioses and through the chitobiases to monosaccharides

Applications

Chitin can be processed further into different derivatives.  The two main derivatives are chitosan and amino glucose.

Chitin applications in cosmetics

  • as carboxymethyl chitin (moisturizers, changes flow properties), antistatic effect due to cationic properties   (hair products)

Chitin applications in medicine / pharmaceutics

  • wound and burn treatment
  • hemostatic for orthopedic treatment of broken bones
  • viscoelastic solutions for ophthamology and orthopedic surgery
  • abdominal adhesions treatment
  • as antibacterial and antifungal agents and for treatment of mucous membranes
  • in tumor therapies
  • in micro surgery, neurosurgery
  • for treatment of chronic wounds, ulcers and bleeding (chitin powder)

Congress

Welcome to
ICCC / EUCHIS 2015
12th International Conference of the European Chitin Society
13th International Conference on Chitin and Chitosan
in Münster, Germany from
August 30th to September 2nd, 2015
http://chitin2015.eu/

Contact

  • Heppe Medical Chitosan GmbH
    Heinrich-Damerow-Strasse 1
    06120 Halle (Saale)
    Germany
  • Tel.: +49 (0) 345 27 996 300
    Fax: +49 (0) 345 27 996 378
  • sales@medical-chitosan.com