Around one third of all type-2 diabetes sufferers develop diabetic foot ulcers in the course of their disease. Due to biofilm formation and multi-resistant bacteria, inflammation occurs in 50% of those affected. This article presents a study investigating the treatment of these with chitosan-containing metallic nanoparticles coupled to toluidine blue as a photosensitizer.

Various polysaccharides such as chitosan and β-glucan possess immunological properties that are advantageous for vaccine adjuvants. Therefore, in the presented study, chitosan and carboxymethyl-β-glucan were combined as nanoparticles, coupled to the model antigen ovalbumin as vaccine adjuvant and investigated in vivo in a mouse model.