therapy

Diabetes mellitus can have serious consequences such as blindness, heart disease, strokes or amputations. In this publication, chitosan nanoparticles will be synthesized to improve the transport of APIs.

Cancer is difficult to treat due to its early immune invasion and metastasis. In the study presented here, the frequently used chemotherapeutic drugs 5-flourouracil and cisplatin are encapsulated in TPP cross-linked chitosan nanoparticles and their in vitro anti-cancer effect is investigated.

Around one third of all type-2 diabetes sufferers develop diabetic foot ulcers in the course of their disease. Due to biofilm formation and multi-resistant bacteria, inflammation occurs in 50% of those affected. This article presents a study investigating the treatment of these with chitosan-containing metallic nanoparticles coupled to toluidine blue as a photosensitizer.

231 articles about chitosan and chitosan derivatives have been published in May and June 2013. The main topics focused on animal and human studies and on chitosan-based nanoparticles and pharmaceutical preparations. Moreover, the physico-chemical properties and pH sensitivity of various chitosan derivatives were intensively studied. Among the top nations of chitosan research are again: China (76 articles), USA (30) and India (14).

At the end of the year 2014 numerous articles about chitosan and chitosan derivatives were published.  All in all 312 reports were released in November and December by leading scientists from China (89 articles), USA (35) India (28) and South Korea (21).