Publications February 2012

Overall 66 articles about chitosan and its derivatives were published in February 2012. With overall 15 articles, this month again China is the country with most publications.

Top Journals	Publications
Colloids Surfaces B: Biointerfaces	6
Biomaterials	5
Tissue Engineering Part A	4
Carbohydrate Research	3
Journal of Colloid and Interface Science	3
Journal of Pharmaceutical Sciences	3

Table: Journals with the most publications about chitosan and chitosan derivatives.

In the following two articles about chitosan derivatives and their usage in dermatological applications will be introduced. The first article is about wound care. Skin whitening is the topic of the second article.

Synthesis of a chitosan derivative soluble at neutral pH and gellable by freeze-thawing, and its application in wound care.

T. Takei, H. Nakahara, H. Ijima, K. Kawakami, Acta biomaterialia 02/2012; 8(2):686-93.

In this study a chitosan-gluconic acid conjugate was developed. This cryogel supports wound healing.

In comparison to conventional chitosan hydrogels, the conjugate is

•     soluble in an aqueous solution at neutral pH and
•     gellable by freeze-thawing (cryogelation).

The study showed accelerated wound healing of full-thickness skin wounds (concerning the whole derma) in rats.

Quelle: ScienceDirect

Cellular fusion and whitening effect of a chitosan derivative coated liposome.

Y. W. Wang, C. H. Jou, C. C. Hung, M. C. Yang, Colloids Surfaces B: Biointerfaces, 2012 Feb 1;90:169-76.

In this study liposomes were coated with N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (HTCC). This coating was confirmed by infrared spectroscopy.

The coated liposomes were loaded with kojic acid (KA). By blocking the melanin production KA provokes skin whitening. KA is used for example in cosmetic products to minimize pigmented moles.

Results:    The fusion of liposomes with the cell membrane of L929 fibroblasts and B16-F10 melanoma was improved. The cell proliferation of L929 wasn’t affected by HTCC-coated liposomes.
B16-F10 was reduced slightly with a concentration increase of HTCC-liposomes.
The degree of skin whitening was determined based on the melanin content in B16-F10 cells.
Compared to non-coated liposomes, the level of melanin synthesis was lower when KA was delivered with HTCC-coated liposomes.

Source: US National Library of Medicine

Source: GoPubMed