chitosan derivates

Vaccines based on recombinant protein antigens often require immunostimulants. Both nanoparticles and chitosan and its derivatives can enhance immunogenicity. For this reason, in the presented studies, PLGA nanoparticles were functionalized with different chitosan derivatives and optimized as effect enhancers for the pneumococcal protein antigen PspA4Pro.

The development of nanotechnology has opened up new applications in the field of biomedicine. Chitosan and its derivatives can be used in a variety of ways, for example to enable targeted and sustained drug release. To give you an overview, we present a review that deals with the current research on the application of chitosan and its derivatives, especially carboxymthylchitosan (CMC), in biomedicine.

Overall 66 articles about chitosan and its derivatives were published in February 2012. With overall 15 articles, this month again China is the country with most publications.

Do you have an idea for a specific chitin or chitosan product, or have you developed a new derivative? We can make you an offer to manufacture your product on our premises. There are a number of advantages in letting us do the production:

Heppe Medical Chitosan produces not only classical chitins and chitosans but also derivatives of these groups of substances.
Chitosan derivatives are obtained by chemical modification of the reactive chitosan groups (OH-, NH2-).
They have the advantage of possessing the unique pharmacological properties of chitosan, such as

• Anti-bacterial
• Anti-viral
• Hemostatic
• Anti-inflammatory

but at the same time are water soluble. As a result, chitosan derivatives exhibit improved biocompatibility, bioactivity, biodegradability and reduced toxicity. Due to the improved physical and chemical properties, there are extended application possibilities.

Examples of biomedical applications include:

• Medical materials (e.g. wound dressings).
• Nanomaterials e.g. nanoparticles, hydrogels, microspheres
• Drug delivery systems
• Vaccine adjuvants
• Tissue engineering

CHITOSAN DERIVATIVES AT HMC

Our standard range of chitosan derivatives includes:

• Chitosan HCl (in various specification)
• Chitosan glutamate
• Carboxymethyl chitosan
• Chitosan lactate
• Chitosan acetate

In our shop you can directly buy small quantities of chitosan derivatives. For a detailed offer please contact the This email address is being protected from spambots. You need JavaScript enabled to view it. of Heppe Medical Chitosan GmbH. Are you looking for another chitosan derivative? Contact us - we also manufacture on a contract basis.