Vaccines based on recombinant protein antigens often require immunostimulants. Both nanoparticles and chitosan and its derivatives can enhance immunogenicity. For this reason, in the presented studies, PLGA nanoparticles were functionalized with different chitosan derivatives and optimized as effect enhancers for the pneumococcal protein antigen PspA4Pro.

Critical bone defects often require the use of bone grafts or artificial bone substitutes such as calcium phosphate cement (CPC) or magnesium phosphate cement (MPC). In the study presented here, MPC is modified with CMC and sodium alginate to form a novel bone cement and its properties are investigated in vivo and in vitro.

Due to the increase of infectious diseases and the development of antibiotic resistance, new antibacterial substances are needed. In the presented study, novel chitosan-AgIO₃ bionanocomposites were synthesized and their antibacterial properties were investigated.

Clinical studies serve evidence-based medicine and enable the development and application of new, innovative medical products and drugs. At the moment, there are several clinical studies with chitosan-containing products or devices, for example, in relation to wound healing, tumor detection or Covid-19. In this article, we would like to give you an overview of the ongoing studies.