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Chitosan-based wound dressings through 3D bioprinting technology

3D bioprinting can improve the treatment of wounds by producing multifunctional, personalized wound dressings. In the study presented here, hydrogel wound dressings based on galantine, sodium alginate, dopamine and quaternized chitosan with effective antioxidant, antibacterial and biocompatible properties will be fabricated via using this technology.

 

 

Lu Y, Xu J, Su Y, et al., 2023, A biocompatible double-crosslinked gelatin/sodium alginate/dopamine/quaterniazed chitosan hydrogel for wound dressings based on 3D bioprinting technology. Int J Bioprint. https://doi.org/10.18063/ijb.689

A BIOCOMPATIBLE DOUBLE-CROSSLINKED GELANTIN/SODIUM ALGINATE/DOPAMINE/QUATERNIAZED CHITOSAN HYDROGEL FOR WOUND DRESSINGS BASED ON 3D BIOPRINTING TECHNOLOGY

The skin is the largest organ of the human body and susceptible to external injuries. Besides e.g. cuts caused by accidents, chronic infections also play a major role. These can lead to amputation of the affected body part or, in the worst case, even to death. Wound dressings used in treatment protect the injured area and can also promote healing. Hydrogels are of particular interest here because, on the one hand, they provide a moist wound healing climate and promote tissue regeneration. On the other hand, they often have similar properties to the extracellular matrix and protect the healing wounds from retears through their elasticity. Through specific modifications, hydrogels can have antibacterial, anti-inflammatory and antioxidant effects. Since hydrogels are applied directly to the wound, they should be particularly skin-friendly. Ingredients that can improve the hydrogel properties include gelantin, dopamine, sodium alginate or chitosan. Gelantin has excellent biocompatibility and viscoelasticity, while sodium alginate is well suited for crosslinking gel networks. Dopamine is capable of scavenging radical oxygen species and thus has an anti-inflammatory effect. Chitosan is also anti-inflammatory. In addition, chitosan has antibacterial properties, which are particularly interesting for wound dressings, since bacterial resistance is often built up against antibiotics. To improve the water solubility of chitosan, it can be derivatized. In the presented study, chitosan was quaternized for the reason.

3D bioprinting makes it possible to produce wound dressings individually developed to meet the needs of the patient. Compared to conventional wound dressings, these are highly flexible, have good air permeability, and absorb rapidly leaking wound fluid while maintaining a moist wound healing environment.

In the study presented here, hydrogel wound dressings based on galantine, sodium alginate, dopamine, and quaternized chitosan (QCTS) with effective antioxidant, antibacterial, and biocompatible properties were prepared by 3D bioprinting. Chitosan with a deacetylation degree of 90% and an average molecular weight of 2 × 105 g/mol was used for this purpose. If you are looking for comparable products, do not hesitate to visit our Chitosan Online Shop or contact us by This email address is being protected from spambots. You need JavaScript enabled to view it.. Gelantin/sodium alginate/dopamine/QCTS hydrogels (GADQ hydrogels) were prepared with different proportions of QCTS: 0 % (GADQ0%), 0.5 % (GADQ0.5%), 1 % (GADQ1%), and 1.5 % (GADQ1.5%).

RESULTS

  • Successful synthesis of QCTS by modification of quaternary ammonium group on chitosan
  • Successful preparation of GADQ hydrogels with a good tensile strength, swelling ratio and effective antioxidant properties, best results for GADQ1.5%
  • 5% (portion of quaternized chitosan) exhibited 93.17% and 91.06% antibacterial activity against Staphylococcus aureus and Escherichia coli, respectively
  • Relative survival rate of more than 350% for fibroblast cells after 7 days of cultivation on the synthesized hydrogels

Conclusions: In this study, GADQ hydrogels prepared by 3D bioprinting were shown to possess suitable properties for multifunctional wound dressings. In particular, hydrogels with a QCTS content of 1.5% showed the best elongation properties, adequate swelling ratio, stable antioxidant performance (above 70%), and good biocompatibility. They also exhibited the highest antibacterial activity.

Link to article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132973/

chitosan, hydrogels, wound treatment, wound dressing, chitosan derivate, 3D Bioprinting

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