Chitosan microparticles with gelatin coating: targeted drug delivery for the lungs
A novel approach to targeted drug release in the lungs
Innovative therapeutics increasingly require highly specialized delivery systems. In the recent publication “Dual-sensitive gelatin-coated chitosan microparticles (GL-ChMPs) for targeted lung delivery”, researchers present a promising strategy: chitosan-based microparticles coated with gelatin that can transport drugs directly to the lungs – smart, sensitive, and efficient.
Water-soluble drug release by chitosan microparticles
Chitosan and chitosan derivatives are promising biopolymers for nasal or vaginal drug delivery using micro- or nanoparticles. However, the pH-dependent solubility of chitosan and excessive water uptake in the presence of ions is suboptimal. Water uptake can result in rapid initial release of the drug due to collapse of the chitosan-based transport vehicle. To stabilize the drug release, research is being conducted to modify the polymer structure by physical crosslinking. Aim of the presented study was to investigate the influence of microparticle composition, in particular the amount of ion crosslinker (CF) introduced, on the release profile of water-soluble drugs from the chitosan matrix.