Eye diseases are difficult to treat due to natural factors such as the blood-eye barrier, cornea or tear film. Polymer-based nanoparticles made of chitosan, among others, can help there to improve drug transport. In this article we would like to summarize a review on this topic.

The dry eye disease (keratoconjunctivitis sicca) is a widespread disease that leads to an unstable tear film, ocular discomfort and visual disturbances. As the tear film fails to cover the entire conjunctiva and cornea, chronic inflammation of the ocular surface occurs. Here we present two studies where the use of chitosan-based eye drops improved the treatment of the disease.