Influence of different chitosan derivatives on the immunogenicity of PLGA nanoparticles
Vaccines based on recombinant protein antigens often require immunostimulants. Both nanoparticles and chitosan and its derivatives can enhance immunogenicity. For this reason, in the presented studies, PLGA nanoparticles were functionalized with different chitosan derivatives and optimized as effect enhancers for the pneumococcal protein antigen PspA4Pro.